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PDIC-NC is an activator of stimulator of interferon genes (STING) and an anticancer agent.1,2 It increases the levels of phosphorylated STING in Lewis lung carcinoma cells when used at a concentration of 2 µM.1 PDIC-NC decreases the viability of A549 and NCI H446 lung cancer cells (IC50s = 0.48 and 0.79 µg/ml, respectively).2 It increases the levels of reactive oxygen species (ROS) and decreases the oxygen consumption rate (OCR) in A549 and NCI H446 cells when used at concentrations of 1 and 2 µg/ml, respectively. PDIC-NC selectively accumulates in the lungs over the heart, liver, spleen, and kidneys in mice. Intravenous administration of PDIC-NC (2 mg/kg) reduces tumor volume and the number of metastases in A549 mouse xenograft models.WARNING This product is not for human or veterinary use. | [References]
[1] XUEJIE ZHAO. Sulfonated Perylene as Three-in-One STING Agonist for Cancer Chemo-Immunotherapy[J]. Angewandte Chemie International Edition, 2024, 63 11. DOI: 10.1002/anie.202318799
[2] DR. ZHONGHUA LIU. Regulating Twisted Skeleton to Construct Organ-Specific Perylene for Intensive Cancer Chemotherapy[J]. Angewandte Chemie International Edition, 2021, 60 29: 16215-16223. DOI: 10.1002/anie.202105607 |
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