| Chemical Properties | Back Directory | [Boiling point ]
480.515±45.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.572±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
10.717±0.40(predicted) |
| Hazard Information | Back Directory | [Uses]
HIF-2α-IN-9 (compound 35r) is an inhibitor ofHIF-2α. HIF-2α-IN-9 inhibits VEGF-A (IC50=305 nM), and regulates growth-promoting genes in tumor cells, reactivates macrophage-mediated tumor immunity[1]. | [References]
[1] Buchstaller H P, et al. Discovery of Cycloalkyl [c] thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2伪 Inhibitors[J]. Journal of Medicinal Chemistry, 2023.. |
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