| Identification | Back Directory | [Name]
Benzamide, N-[4-[[7-chloro-2,3,4,5-tetrahydro-5-[[3-(4-morpholinyl)-3-oxopropyl]amino]-1H-1-benzazepin-1-yl]carbonyl]-3-methylphenyl]-2-methyl- | [CAS]
2648650-50-2 | [Synonyms]
Vasopressin V2 receptor antagonist 1
Benzamide, N-[4-[[7-chloro-2,3,4,5-tetrahydro-5-[[3-(4-morpholinyl)-3-oxopropyl]amino]-1H-1-benzazepin-1-yl]carbonyl]-3-methylphenyl]-2-methyl- | [Molecular Formula]
C33H37ClN4O4 | [MOL File]
2648650-50-2.mol | [Molecular Weight]
589.12 |
| Hazard Information | Back Directory | [Uses]
Vasopressin V2 receptor antagonist 1 (Compound 4g) is a vasopressin V2 receptor (V2R) antagonist with a Ki of 3.8 nM. Vasopressin V2 receptor antagonist 1 can be used for autosomal dominant polycystic kidney disease (ADPKD) research[1]. | [References]
[1] Haoran Zhang, et al. Long Residence Time at the Vasopressin V2 Receptor Translates into Superior Inhibitory Effects in Ex Vivo and In Vivo Models of Autosomal Dominant Polycystic Kidney Disease. J Med Chem. 2022 Apr 1. DOI:10.1021/acs.jmedchem.2c00011 |
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