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2651200-35-8

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2651200-35-8 Structure

2651200-35-8 Structure
IdentificationBack Directory
[Name]

Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-8-(trifluoromethyl)-
[CAS]

2651200-35-8
[Synonyms]

CDK12-IN-5
Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-8-(trifluoromethyl)-
[Molecular Formula]

C18H15F5N8O
[MOL File]

2651200-35-8.mol
[Molecular Weight]

454.36
Chemical PropertiesBack Directory
[density ]

1.77±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

8.87±0.30(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

CDK12-IN-5, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 23.9 nM at high ATP (2 mM). CDK12-IN-5 has no effect on CDK2/Cyclin E (IC50=173 μM) and CDK9/Cyclin T1 (IC50=127 μM) at high ATP (2 mM) (WO2021116178A1)[1].
[IC 50]

CDK12: 23.9 nM (IC50); CDK2/cyclinE: 173 μM (IC50); CDK9/cyclinT1: 127 μM (IC50)
[References]

[1] Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.
Spectrum DetailBack Directory
[Spectrum Detail]

Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-8-(trifluoromethyl)-(2651200-35-8)1HNMR
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