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2681278-09-9

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2681278-09-9 Structure

2681278-09-9 Structure
IdentificationBack Directory
[Name]

5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]-
[CAS]

2681278-09-9
[Synonyms]

IRAK4-IN-10
5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]-
[Molecular Formula]

C22H24N8
[MOL File]

2681278-09-9.mol
[Molecular Weight]

400.48
Chemical PropertiesBack Directory
[Boiling point ]

726.9±70.0 °C(Predicted)
[density ]

1.44±0.1 g/cm3(Predicted)
[pka]

14.03±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

IRAK4-IN-10 (compound 75) is a potent IRAK4 inhibitor with an IC50 of 1.5 nM. IRAK4-IN-10 blocks MyD88 dependent signaling. IRAK4-IN-9 has the potential for the research of inflammatory diseases, autoimmune diseases, and cancer[1].
[IC 50]

IRAK4: 1.5 nM (IC50)
[References]

[1] Sabnis RW. Novel Tricyclic Heteroaryl Compounds as IRAK4 Inhibitors for Treating Cancer, Autoimmune and Inflammatory Diseases. ACS Med Chem Lett. 2022 Feb 28;13(3):336-337. DOI:10.1021/acsmedchemlett.2c00060
Spectrum DetailBack Directory
[Spectrum Detail]

5H-Pyrido[3,2-b]indole-7-carbonitrile, 4-[(1-methylethyl)amino]-3-[1-(4-piperidinyl)-1H-1,2,3-triazol-4-yl]-(2681278-09-9)1HNMR
2681278-09-9 suppliers list
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Telephone: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: TargetMol Chemicals Inc.  
Telephone: 15002134094
Website: https://www.targetmol.cn/
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