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2681278-07-7

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2681278-07-7 Structure

2681278-07-7 Structure

Identification	Back Directory
[Name] 5H-Pyrido[3,2-b]indole-7-carbonitrile, 3-[1-(3-methylbutyl)-1H-1,2,3-triazol-4-yl]-4-[(1-methylethyl)amino]-
[CAS] 2681278-07-7
[Synonyms] IRAK4-IN-9 5H-Pyrido[3,2-b]indole-7-carbonitrile, 3-[1-(3-methylbutyl)-1H-1,2,3-triazol-4-yl]-4-[(1-methylethyl)amino]-
[Molecular Formula] C22H25N7
[MOL File] 2681278-07-7.mol
[Molecular Weight] 387.48

Chemical Properties	Back Directory
[Boiling point ] 665.2±65.0 °C(Predicted)
[density ] 1.29±0.1 g/cm3(Predicted)
[pka] 14.06±0.40(Predicted)

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[Uses] IRAK4-IN-9 (compound 73) is a potent IRAK4 inhibitor with an IC50 of 1.5 nM. IRAK4-IN-9 blocks MyD88 dependent signaling. IRAK4-IN-9 has the potential for the research of inflammatory diseases, autoimmune diseases, and cancer[1].
[IC 50] IRAK4: 1.5 nM (IC₅₀)
[References] [1] Sabnis RW. Novel Tricyclic Heteroaryl Compounds as IRAK4 Inhibitors for Treating Cancer, Autoimmune and Inflammatory Diseases. ACS Med Chem Lett. 2022 Feb 28;13(3):336-337. DOI:10.1021/acsmedchemlett.2c00060

2681278-07-7 suppliers list

Company Name:	TargetMol Chemicals Inc.
Telephone:	15002134094
Website:	https://www.targetmol.cn/

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