| Identification | More | [Name]
Benzylhydroxylamine hydrochloride | [CAS]
2687-43-6 | [Synonyms]
benzylhydroxylamine hydrochloride
BENZYLOXYAMINE
BENZYLOXYAMINE HCL
BENZYLOXYAMINE HYDROCHLORIDE
LABOTEST-BB LT00233131
O-BENZYLHYDROXYLAMINE HCL
O-BENZYLHYDROXYLAMINE HYDROCHLORIDE
O-BENZYLHYDROXYLAMMONIUM CHLORIDE
TIMTEC-BB SBB003971
o-benzyl-hydroxylaminhydrochloride
O-BENZYLHYDROXYLAMINE CHLORHYDRATE
orthoBenzyl Hydroxylamine HCl
BENZYLOXYLAMINE HYDROCHLORIDE
2-BenzylhydroxylamineHcl
O-Benzylhydroxylaminehydrochloride,99%
Hydroxylamine, O-(phenylmethyl)-, hydrochloride
β-benzylhydroxylamine
α-benzylhydroxylmine
Benzyloxyammonium Chloride
O-(Phenylmethyl)hydroxylamine Hydrochloride | [EINECS(EC#)]
220-249-0 | [Molecular Formula]
C7H10ClNO | [MDL Number]
MFCD00012952 | [Molecular Weight]
159.61 | [MOL File]
2687-43-6.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powde | [Melting point ]
238 °C (subl.)(lit.)
| [storage temp. ]
Store at RT. | [solubility ]
Soluble in DMSO and methanol. | [form ]
Crystalline Powder or Flakes | [color ]
White to almost white | [PH]
2.2～3.2 (10g/l, 25℃) | [Sensitive ]
Hygroscopic | [Usage]
A reagent used for the synthesis of hydroxylamines and hydroxyamates | [Detection Methods]
T,NMR | [BRN ]
3595440 | [InChI]
InChI=1S/C7H9NO.ClH/c8-9-6-7-4-2-1-3-5-7;/h1-5H,6,8H2;1H | [InChIKey]
HYDZPXNVHXJHBG-UHFFFAOYSA-N | [SMILES]
C1(CON)=CC=CC=C1.Cl | [CAS DataBase Reference]
2687-43-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H315-H317-H318 | [Precautionary statements ]
P261-P264-P272-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S8:Keep container dry .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
NC3040000
| [F ]
3 | [TSCA ]
Yes | [HS Code ]
29280000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Dam. 1
Skin Irrit. 2
Skin Sens. 1 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powde | [Uses]
O-Benzylhydroxylamine hydrochloride is a reagent used for the synthesis of hydroxylamines and hydroxyamates.
| [Synthesis]
Add the O-benzylacetoxime to a mixed solution of 17 g of methanol and 200 g of a 38% mass concentration hydrochloric acid solution; react for 210 minutes at a temperature of 36°C and a stirring speed of 90 rpm; then distill under reduced pressure at a temperature of 65°C until a solid precipitate out, and cool to room temperature. The solid was washed with petroleum ether (100mL×3) and dried under vacuum at 80°C for 8 hours to obtain 95.18g of the target product O-Benzylhydroxylamine hydrochloride, with a purity of 99.87%; the yield is 98.72%.
 | [Purification Methods]
Recrystallise the hydrochloride from H2O or EtOH. [Beilstein 6 IV 2562.] | [References]
[1] Journal of Organic Chemistry, 1997, vol. 62, # 26, p. 9177 - 9181
[2] Patent: US2014/378399, 2014, A1. Location in patent: Paragraph 0092
[3] Journal of Pharmacology and Experimental Therapeutics, 1999, vol. 288, # 2, p. 490 - 501
[4] Synthetic Communications, 1997, vol. 27, # 7, p. 1143 - 1147
[5] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 10, p. 3233 - 3241 |
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