| Identification | Back Directory | [Name]
4-(6,7-dimethoxyquinazolin-4-yl)-1,4-diazepane-1-sulfonamide hydrochloride | [CAS]
2687222-59-7 | [Synonyms]
Enpp-1-IN-14
4-(6,7-dimethoxyquinazolin-4-yl)-1,4-diazepane-1-sulfonamide hydrochloride | [Molecular Formula]
C15H22ClN5O4S | [MOL File]
2687222-59-7.mol | [Molecular Weight]
403.88 |
| Hazard Information | Back Directory | [Uses]
Enpp-1-IN-14 (Compound 015) is a potent Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) inhibitor with an IC50 value of 32.38 nM for recombinant human ENPP-1. Enpp-1-IN-14 has anti-tumor activity[1]. | [in vivo]
Enpp-1-IN-14 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth[1]. | Animal Model: | Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×105 MC38 cells)[1] | | Dosage: | 50 mg/kg | | Administration: | IP; BID, for 31 days (given a single 10 Gy exposure of focal radiation to the tumor site) | | Result: | Significantly inhibited tumor growth. |
| [storage]
Store at -20°C | [References]
[1] Srinivas Rao Kasibhatla, et al. Inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 1 (enpp1) and methods of use thereof. WO2021158829A1. |
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