| Identification | Back Directory | [Name]
Benzonitrile, 3-amino-5-methoxy- (9CI) | [CAS]
269411-71-4 | [Synonyms]
3-aMino-5-Methoxybenzonitrile
Benzonitrile,3-aMino-5-Methoxy-
Benzonitrile, 3-amino-5-methoxy- (9CI) | [Molecular Formula]
C8H8N2O | [MDL Number]
MFCD18389726 | [MOL File]
269411-71-4.mol | [Molecular Weight]
148.16 |
| Chemical Properties | Back Directory | [Melting point ]
81-85 °C | [Boiling point ]
322.6±27.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
2.37±0.10(Predicted) | [Appearance]
Light yellow to brown Solid |
| Hazard Information | Back Directory | [Synthesis]
In a three-necked flask, 3-methoxy-5-nitrobenzonitrile (8.0 g, 0.045 mol) was dissolved in methanol (80 mL), 10% palladium-carbon catalyst (1.4 g) and ammonium acetate (6.9 g, 0.090 mol) were added. Hydrogen was introduced and the reaction was stirred at 40 °C for 8 hours. After completion of the reaction, filtration was carried out and the filter cake was washed with methanol (15 mL x 3). The filtrates were combined and concentrated under reduced pressure. The concentrate was poured into 50 mL of water and extracted with ethyl acetate (40 mL x 3). The organic phases were combined, dried with anhydrous sodium sulfate, and the solvent was removed by evaporation under reduced pressure to give 3-amino-5-methoxybenzonitrile as a solid 6.5 g in 98.2% yield. | [References]
[1] Patent: CN107573264, 2018, A. Location in patent: Paragraph 0023-0025; 0040-0042; 0057-0059; 0074-0076 |
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