| Identification | Back Directory | [Name]
4-[[4-(1H-benzimidazol-2-yl)phenyl]amino]-4-keto-butyric acid | [CAS]
27031-00-1 | [Synonyms]
iGP-1
4-[[4-(1H-benzimidazol-2-yl)phenyl]amino]-4-oxobutanoic acid
4-{[4-(1H-benzimidazol-2-yl)phenyl]amino}-4-oxobutanoic acid
4-[[4-(1H-benzimidazol-2-yl)phenyl]amino]-4-keto-butyric acid
4-[[4-(1H-benzimidazol-2-yl)phenyl]amino]-4-oxo-butanoic acid
4-((4-(1H-Benzo[d]imidazol-2-yl)phenyl)amino)-4-oxobutanoic acid | [Molecular Formula]
C17H15N3O3 | [MDL Number]
MFCD00395378 | [MOL File]
27031-00-1.mol | [Molecular Weight]
309.32 |
| Chemical Properties | Back Directory | [density ]
1.398±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 50 mg/ml). | [form ]
solid | [pka]
4.48±0.10(Predicted) | [color ]
Beige | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| Hazard Information | Back Directory | [Description]
iGP-1 (27031-00-1) is a potent and cell permeable inhibitor of mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH), IC50=6.3 μM, that is selective over the cytosolic enzyme1. It does not block pyruvate uptake into cells or mitochondria and has no direct effect on glycolysis in synaptosomes. This novel inhibitor is a unique tool which may be used to investigate the role of glycerol-3-phosphate metabolism in isolated and intact systems.1 | [Uses]
iGP-1 is a selective and cell-permeant mitochondrial sn-glycerol 3-phosphate dehydrogenase (mGPDH) inhibitor. iGP-1 inhibits H2O2 production by mGPDH[1]. | [References]
1) Orr?et al.?(2014),?Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase; PLoS One,?9?e89938 |
|
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Matrix Scientific
|
| Tel: |
803 788-9494 All other calls |
| Website: |
www.matrixscientific.com |
|