| Identification | Back Directory | [Name]
2-[3-Chloro-4-(1,1-dimethylethyl)phenyl]-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-7-fluoro-1,2,3,4-tetrahydro-1-oxo-4-isoquinolineacetic acid | [CAS]
2706536-26-5 | [Synonyms]
2-[3-Chloro-4-(1,1-dimethylethyl)phenyl]-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-7-fluoro-1,2,3,4-tetrahydro-1-oxo-4-isoquinolineacetic acid | [Molecular Formula]
C29H27ClFNO5 | [MOL File]
2706536-26-5.mol | [Molecular Weight]
523.98 |
| Chemical Properties | Back Directory | [Boiling point ]
685.0±55.0 °C(Predicted) | [density ]
1.322±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [solubility ]
DMF: 10 mg/ml
DMF: PBS (pH 7.2) (1:8): 0.11 mg/ml
DMSO: 5 mg/ml | [pka]
4.35±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
STING18 (Stimulator of interferon genes 18) is a compound that inhibits STING protein by utilizing a small molecule active site dimer, with good oral exposure, slow binding kinetics, and functional inhibitory activity on STING-mediated cytokine release. | [References]
[1] Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING |
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