ChemicalBook--->CAS DataBase List--->2733575-91-0

2733575-91-0

2733575-91-0 Structure

2733575-91-0 Structure
IdentificationBack Directory
[Name]

Carbamic acid, N-(1-methylethyl)-, (1R,3S)-3-[5-[[[3-(methoxymethyl)-1-methyl-1H-pyrazol-5-yl]carbonyl]amino]-1H-pyrazol-3-yl]cyclopentyl ester, hydrate (1:1)
[CAS]

2733575-91-0
[Synonyms]

Carbamic acid, N-(1-methylethyl)-, (1R,3S)-3-[5-[[[3-(methoxymethyl)-1-methyl-1H-pyrazol-5-yl]carbonyl]amino]-1H-pyrazol-3-yl]cyclopentyl ester, hydrate (1:1)
[Molecular Formula]

C19H30N6O5
[MOL File]

2733575-91-0.mol
[Molecular Weight]

422.49
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

PF-07104091 hydrate is a potent and selective CDK2/cyclin E1 and GSK3β inhibitor, with Kis of 1.16 and 537.81 nM, respectively. PF-07104091 hydrate has anti-tumor activity for cyclin E1-amplified cancers. (patent WO2020157652A2).
[IC 50]

CDK2/cyclin E1: 1.16 nM (Ki); GSK3β: 537.81 nM (Ki)
[References]

[1] Douglas Carl BEHENNA, et al. Cdk2 inhibitors. WO2020157652A2.
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Company Name: Guangzhou Younan Technology Co., Ltd  
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Company Name: Aikon International Limited  
Telephone: 025-58859352 18651614124
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