Identification | Back Directory | [Name]
2(3H)-Benzoxazolone, 3-[(3-methoxyphenyl)methyl]-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)- | [CAS]
2754265-66-0 | [Synonyms]
TNIK-IN-5 3-(3-methoxybenzyl)-6-(3H-pyrrolo[2,3-b]pyridin-5-yl)benzo[d]oxazol-2(3H)-one 3-(3-methoxybenzyl)-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)benzo[d]oxazol-2(3H)-one 2(3H)-Benzoxazolone, 3-[(3-methoxyphenyl)methyl]-6-(1H-pyrrolo[2,3-b]pyridin-5-yl)- inhibit,Colorectal cancer,TNIK,Wnt,Cell proliferation,Inhibitor,TNIKIN5,Wnt pathway,Migration,HCT116?cells,TNIK IN 5 | [Molecular Formula]
C22H17N3O3 | [MOL File]
2754265-66-0.mol | [Molecular Weight]
371.39 |
Hazard Information | Back Directory | [Uses]
TNIK-IN-5 is an efficient TNIK inhibitor with IC50 of 0.05 μM. TNIK-IN-5 efficiently inhibits Wnt signaling in intact cells. TNIK-IN-5 shows excellent in vitro anti-colorectal cancer activity[1]. | [References]
[1] Luo X, Yang R, Li Y, Zhang L, Yang S, Li L. Discovery of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer. Bioorg Med Chem Lett. 2022;67:128745. DOI:10.1016/j.bmcl.2022.128745 |
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