| Identification | Back Directory | [Name]
5-Pyrimidinecarboxamide, N-[4-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-1-piperazinyl]carbonyl]-1-piperidinyl]phenyl]-2-phenoxy- | [CAS]
2761281-50-7 | [Synonyms]
PROTAC(H-PGDS)-7
5-Pyrimidinecarboxamide, N-[4-[4-[[4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-1-piperazinyl]carbonyl]-1-piperidinyl]phenyl]-2-phenoxy- | [Molecular Formula]
C40H38N8O7 | [MOL File]
2761281-50-7.mol | [Molecular Weight]
742.78 |
| Chemical Properties | Back Directory | [density ]
1.428±0.06 g/cm3(Predicted) | [solubility ]
DMSO: 10 mg/ml | [form ]
Solid | [pka]
10.75±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
PROTAC(H-PGDS)-7 is a Hematopoietic prostaglandin D synthase (H-PGDS) molecular glue degrader, with a DC50 of 17.3 pM[1]. | [IC 50]
DP | [References]
[1] Hidetomo Yokoo, et al. Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design. J Med Chem. 2021 Nov 11;64(21):15868-15882. DOI:10.1021/acs.jmedchem.1c01206 |
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