| Chemical Properties | Back Directory | [density ]
1.283±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
14.693±0.70(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NPR-C activator 1 (Compound 1) is a potent activator of natriuretic peptide receptor C (NPR-C). C-type natriuretic peptide (CNP) is involved in the regulation of vascular homeostasis. NPR-C activator 1 is identified as a potent agonist (EC50 ～ 1 μM) with promising in vivo pharmacokinetic properties[1]. | [References]
[1] Smith RJ, et al. A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C. J Med Chem. 2022 Apr 14;65(7):5495-5513. DOI:10.1021/acs.jmedchem.1c01974 |
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