| Identification | Back Directory | [Name]
L-Proline, 4-[([1,1'-biphenyl]-4-ylmethyl)amino]-, (4S)- | [CAS]
2768663-14-3 | [Synonyms]
SN40
L-Proline, 4-[([1,1'-biphenyl]-4-ylmethyl)amino]-, (4S)- | [Molecular Formula]
C18H20N2O2 | [MOL File]
2768663-14-3.mol | [Molecular Weight]
296.36 |
| Chemical Properties | Back Directory | [Boiling point ]
511.2±50.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
2.10±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SN40 is a potent amino acid transport (AAT) inhibitor with Kis of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN40 can be used for researching anticancer[1]. | [IC 50]
EAAT1: 2.94 μM (Ki); EAAT2: 5.55 μM (Ki); EAAC1: 24.43 μM (Ki); EAAT5: 5.55 μM (Ki); human ASCT2: 2.42 μM (Ki); rat ASCT2: 7.29 μM (Ki) | [References]
[1] Grewer Christof, et al. Preparation of amino acids as inhibitors of alanine serine cysteine transporter 2. World Intellectual Property Organization, WO2022087630 A1 2022-04-28 |
|
|