| Chemical Properties | Back Directory | [Boiling point ]
518.5±50.0 °C(Predicted) | [density ]
1.369±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
12.94±0.29(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
GFB-12811 is a high selective and orally active CDK5 inhibitor with an IC50 of 2.3 nM. GFB-12811 is highly selective over the other tested kinases (CDK1/2/6/7/9)[1]. | [Biological Activity]
GFB-12811 is a high selective and orally active CDK5 inhibitor with an IC50 of 2.3 nM. GFB-12811 is highly selective over the other tested kinases (CDK1/2/6/7/9)[1]. | [IC 50]
Cdk5/p25: 2.3 nM (IC50); CDK2/CycA: 211 nM (IC50); CDK7/Cyclin H/MAT1: 718 nM (IC50); CDK9/CycT1: 894 nM (IC50) | [References]
[1]. Daniels MH, et al. Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022;65(4):3575-3596. |
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