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2785430-89-7

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2785430-89-7 Structure

2785430-89-7 Structure
IdentificationBack Directory
[Name]

2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]-
[CAS]

2785430-89-7
[Synonyms]

ALK5-IN-33
2,4-Pyrimidinediamine, N4-(8-methyl-4-cinnolinyl)-N2-[4-(4-morpholinyl)phenyl]-
[Molecular Formula]

C23H23N7O
[MOL File]

2785430-89-7.mol
[Molecular Weight]

413.48
Chemical PropertiesBack Directory
[Boiling point ]

690.5±65.0 °C(Predicted)
[density ]

1.341±0.06 g/cm3(Predicted)
[pka]

6.00±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

ALK5-IN-33 (Compound EX-10) is a selective, orally active ALK-5 inhibitor with an IC50 ≤10 nM[1].
[in vivo]

ALK-IN-33 (Compound EX-10) (10-100 mg/kg; i.g.; once) reduces the phospho SMAD2 levels in a dose dependent fashion in A549 xenograft model in mice[1].

Animal Model:Female athymic nude mice, A549 xenograft model[1]
Dosage:10, 50, 75 and 100 mg/kg
Administration:Oral gavage, once
Result:Reduced the phospho SMAD2 levels (p-SMAD2) in a dose dependent fashion.
[IC 50]

ALK5: ≤10 nM (IC50); ALK2
[References]

[1] Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1.
2785430-89-7 suppliers list
Company Name: TargetMol Chemicals Inc.  
Telephone: 15002134094
Website: https://www.targetmol.cn/
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