| Chemical Properties | Back Directory | [Boiling point ]
593.053±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.195±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
Acetonitrile: Slightly soluble: 0.1-1 mg/ml
Chloroform: Sparingly soluble: 1-10 mg/ml | [form ]
Solid | [pka]
6.687±0.10(predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
WLB-89462 (Compound 20c) is a selective σ2 receptor ligand (Ki: 13 nM). WLB-89462 has neuroprotective activity. WLB-89462 improves short-term memory impairment induced by Aβ peptide in rats. WLB-89462 has good ADMET profile (good solubility, no CYP inhibition, good metabolic stability, high permeability, brain penetration, and high oral exposure in rodents)[1]. | [References]
[1] Christmann U, et al. Discovery of WLB-89462, a New Drug-like and Highly Selective σ2 Receptor Ligand with Neuroprotective Properties. J Med Chem. 2023 Sep 14;66(17):12499-12519. DOI:10.1021/acs.jmedchem.3c01060 |
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