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2860554-32-9

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2860554-32-9 Structure

2860554-32-9 Structure

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[Name] Sigma-2 Radioligand 1
[CAS] 2860554-32-9
[Synonyms] Sigma-2 Radioligand 1

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[Uses] Sigma-2 Radioligand 1 (compound 1) is a Sigma-2 selective ligand. Sigma-2 Radioligand 1 has good biodistribution in mice and good in vivo activity in rats. [18F] Modified Sigma-2 Radioligand 1 for visualization of tumors in micro-PET/CT imaging, exhibiting high tumor uptake and tumor-to-background ratio. Experiments show that Sigma-2 Radioligand 1 binds highly specifically in U87MG glioma xenografts[1].
[References] [1] Wang T, et al. Development of a Highly Specific 18F-Labeled Radioligand for Imaging of the Sigma-2 Receptor in Brain Tumors. J Med Chem. 2023 Sep 13.. . DOI:10.1021/acs.jmedchem.3c00735

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