| Identification | Back Directory | [Name]
2-Propen-1-one, 3-(4-chlorophenyl)-1-(1,3,4,9-tetrahydro-6-methoxy-1-methyl-2H-pyrido[3,4-b]indol-2-yl)-, (2E)- | [CAS]
2891824-14-7 | [Synonyms]
2-Propen-1-one, 3-(4-chlorophenyl)-1-(1,3,4,9-tetrahydro-6-methoxy-1-methyl-2H-pyrido[3,4-b]indol-2-yl)-, (2E)- | [Molecular Formula]
C22H21ClN2O2 | [MOL File]
2891824-14-7.mol | [Molecular Weight]
380.87 |
| Chemical Properties | Back Directory | [Boiling point ]
630.6±55.0 °C(predicted) | [density ]
1.287±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
16.94±0.40(predicted) |
| Hazard Information | Back Directory | [Uses]
Dyrk1A-IN-10 (compound B4) is a DYRK1A inhibitor with antidiabetic activity. Dyrk1A-IN-10 can promote pancreatic β-cell proliferation, increase insulin secretion, and lower blood sugar[1]. | [References]
[1] Li Guan, et al. "Design, synthesis, and biological evaluation of β-carboline-cinnamic acid derivatives as DYRK1A inhibitors in the treatment of diabetes." Bioorganic Chemistry (2024): 107676. DOI:10.1016/j.bioorg.2024.107676 |
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