| Identification | Back Directory | [Name]
PBOX-6 | [CAS]
290814-68-5 | [Synonyms]
PBOX-6
PBOX-6 >=98% (HPLC)
Carbamic acid, N,N-dimethyl-, 6-(1-naphthalenyl)pyrrolo[2,1-d][1,5]benzoxazepin-7-yl ester | [Molecular Formula]
C25H20N2O3 | [MDL Number]
MFCD31382391 | [MOL File]
290814-68-5.mol | [Molecular Weight]
396.44 |
| Chemical Properties | Back Directory | [Melting point ]
177-179 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
580.6±50.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO | [form ]
powder | [pka]
-1.32±0.70(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound, acts as a microtubule-depolymerizing agent and an apoptotic agent. | [References]
[1] Zisterer DM, et al. Pyrrolo-1,5-benzoxazepines induce apoptosis in HL-60, Jurkat, and Hut-78 cells: a new class of apoptotic agents. J Pharmacol Exp Ther. 2000 Apr;293(1):48-59. PMID:10734152
[2] Mc Gee MM, et al. Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6. FEBS Lett. 2002 Mar 27;515(1-3):66-70. DOI:10.1016/s0014-5793(02)02440-7
[3] Bane FT, et al. The microtubule-targeting agents, PBOX-6 [pyrrolobenzoxazepine 7-[(dimethylcarbamoyl)oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine] and paclitaxel, induce nucleocytoplasmic redistribution of the peptidyl-prolyl isomerases, cyclophilin A and pin1, in malignant hematopoietic cells. J Pharmacol Exp Ther. 2009 Apr;329(1):38-47. DOI:10.1124/jpet.108.148130 |
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