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2922814-80-8

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2922814-80-8 Structure

2922814-80-8 Structure
IdentificationBack Directory
[Name]

NLRP3-IN-28
[CAS]

2922814-80-8
[Synonyms]

NLRP3-IN-28
Hazard InformationBack Directory
[Uses]

NLRP3-IN-28 (compound N77) is a potent inhibitor of NLRP3. NLRP3-IN-28 inhibits Nigericin (HY-127019)-induced pyroptosis with an EC50 of 0.07μM. NLRP3-IN-28 alleviates the inflammatory reaction in vivo[1].
[References]

[1] Zhou N, et al. Discovery of a novel pyroptosis inhibitor acting though modulating glutathionylation to suppress NLRP3-related signal pathway. Int Immunopharmacol. 2024 Jan 25;127:111314. DOI:10.1016/j.intimp.2023.111314
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