| Identification | Back Directory | [Name]
(R)-6-cyclohexyl-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide | [CAS]
2923008-66-4 | [Synonyms]
GSK_WRN4
(R)-6-cyclohexyl-N-(1,1-dioxido-2,3-dihydrothiophen-3-yl)-2-oxo-1,2-dihydropyridine-3-carboxamide |
| Hazard Information | Back Directory | [Uses]
GSK_WRN4 is a WRN helicase inhibitor (pIC50=7.6) with anticancer activity. GSK_WRN4 selectively inhibits the growth of MSI tumor cells in vitro and in vivo by inducing DNA double-strand breaks, particularly at expanded TA repeats and DNA damage regions[1]. | [References]
[1] Picco, et al. "Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells." Cancer Discovery 14.8 (2024): 1457-1475. DOI:10.1158/2159-8290.CD-24-0052 |
|
|