| Identification | More | [Name]
Pirenzepine hydrochloride | [CAS]
29868-97-1 | [Synonyms]
5,11-DIHYDRO-11-[(4-METHYL-1-PIPERAZINYL)ACETYL]-6H-PYRIDO-[2,3-B][1,4] BENZODIAZEPIN-6-ONE DIHYDROBROMIDE
5,11-DIHYDRO-11-[(4-METHYL-1-PIPERAZINYL)ACETYL]-6H-PYRIDO-[2,3-B] [1,4]BENZODIAZEPIN-6-ONE DIHYDROCHLORIDE
5,11-dihydro-11-[(4-methylpiperazin-1-yl)acetyl]-6h-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride
PIRENZEPINE DIHYDROCHLORIDE
PIRENZEPINE HCL HYDRATE
PIRENZEPINE HYDROCHLORIDE
gastrozepin
l-s519
ls519cl2
ls519dihydrochloride
5,11-Dihydro-11-((4-methylpiperazin-1-yl)acetyl)-6H-pyrido(2,3-b)-(1,4)benzodiazepin-6-one dihydrochloride
Pirenzepine HCL
pirenzeping hydrochloride
PIRENZEPINE 2HCL
Duogastral,Durapirenz,Gasteril,Gastrozepin,Leblon,Maghen,Renzepin,Tabe,Ulcuforton,Ulcosan,2HCl
5,11-Dihydro-11-((4-methylpiperazin-1-yl)acetyl)-6H-pyrido(2,3-b)-(1,4)benzodiazepin-6-onedihydrochloride
Pirenzepin2HCl
5,11-dihydro-11-[2-(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzo- diazepin-6-one Dihydrochloride
Duogastral
Durapirenz | [EINECS(EC#)]
249-907-5 | [Molecular Formula]
C19H23Cl2N5O2 | [MDL Number]
MFCD00055214 | [Molecular Weight]
424.32 | [MOL File]
29868-97-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Solid | [Melting point ]
248-250°C | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
H2O: 50 mg/mL
| [form ]
powder
| [color ]
white
| [Water Solubility ]
Soluble to 100 mM in water | [Sensitive ]
Hygroscopic | [Usage]
An antiulcerative. Tricyclic gastric-acid inhibitor | [InChI]
InChI=1S/C19H21N5O2.ClH/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24;/h2-8H,9-13H2,1H3,(H,21,26);1H | [InChIKey]
AFBSBOBDKXETKP-UHFFFAOYSA-N | [SMILES]
C(N1C2=CC=CC=C2C(=O)NC2C=CC=NC1=2)(=O)CN1CCN(C)CC1.Cl | [CAS DataBase Reference]
29868-97-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [WGK Germany ]
2
| [RTECS ]
UU7883000
| [HS Code ]
2933.99.7500 | [Toxicity]
dog,LD50,intravenous,62500ug/kg (62.5mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988. |
| Hazard Information | Back Directory | [Description]
Pirenzepine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 11.48 nM).1 It is selective for M1 over M2, M3, and M4 receptors (Kis = 602.56, 151.36, and 199.53 nM, respectively). Pirenzepine inhibits ascending reflex contraction of the circular smooth muscle in isolated guinea pig ileal segments induced by intraluminal balloon inflation (IC50 = 501.19 nM). It inhibits methacholine-induced increases in ileal pressure in guinea pigs (ID50 = 724.44 nmol/kg). Pirenzepine inhibits oxotremorine-induced gastric ulcer, gastric acid secretion, and salivation in rats (ED50s = 13, 37.5, and 620 μg/kg i.v., respectively).2 It prevents form-deprivation myopia (FDM) in a chick model of experimental myopia.3 | [Chemical Properties]
Solid | [Originator]
Microsules Bernabo, Microsules Bernabo | [Uses]
An antiulcerative. Tricyclic gastric-acid inhibitor | [Uses]
Antiulcerative;M1 antagonist | [Manufacturing Process]
48.4 g of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzo-diazepin-6-one were refluxed in 900 ml of absolute dioxane for 15 minutes. Thereafter, over a period of 45 minutes, 28 ml of chloroacetyl chloride and 52 ml of triethylamine were simultaneously added dropwise to the mixture. The mixture was refluxed for eight hours and then vacuum-filtered after having cooled. The filtrate was evaporated in vacuum. The crystalline residue was recrystallized from acetonitrile in the presence of activated charcoal. MP: 212°-213°C (with decomposition). Yield: 85% of theory.
A mixture of 67.5 g of 11-chloroacetyl-5,11-dihydro-6H-pyrido[2,3b][1,4]benzodiazepin-6-one, 183 ml of N-methylpiperazine and 1.37 liters of absolute benzene was refluxed for 18 hours. Thereafter, the crystalline precipitate was vacuum filtered off, dissolved in aqueous 20% hydrochloric acid, the solution was evaporated in vacuum, the crystalline residue wasdissolved in 250 ml of water while heating, the solution was admixed with 150 ml of isopropanol and active charcoal, filtered, and 2.5 liters of isopropanol were added to the filtrate. After cooling, the precipitate was vacuum filtered off, yielding 70% of theory of the 5,11-dihydro-11-[(4'-methyl-1'-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride, M.P. 257259°C (decomp.).
The free base of pirenzepine, obtained from the dihydrochloride by making an aqueous solution thereof alkaline with dilute sodium hydroxide and extracting it with chloroform, had MP: 226°-228°C after recrystallization from methanol/ether. | [Therapeutic Function]
Antiulcer, Antiemetic | [General Description]
Pirenzepine dihydrochloride is an anticholinergic agent. It is also considered as an antiulcer drug. It is used to treat myopia, gastric and duodenal ulcers. Pirenzepine dihydrochloride induces the dimerization of muscarinic M1 receptors. | [Biochem/physiol Actions]
Selective M1 muscarinic acetylcholine receptor antagonist. | [storage]
Store at 2-8°C | [References]
[1] HENRI N. DOODS . Pharmacological profile of selective muscarinic receptor antagonists on guinea-pig ileal smooth muscle[J]. European journal of pharmacology, 1994, 253 3: Pages 275-281. DOI: 10.1016/0014-2999(94)90202-x
[2] P. DEL SOLDATO. Pharmacodynamic evaluation of selective antimuscarinic properties of pirenzepine in the rat[J]. Pharmacological research communications, 1982, 14 3: Pages 279-287. DOI: 10.1016/s0031-6989(82)80037-4
[3] W ALANA LUFT William K S Yan Ming. Variable effects of previously untested muscarinic receptor antagonists on experimental myopia.[J]. Investigative ophthalmology & visual science, 2003, 44 3: 1330-1338. DOI: 10.1167/iovs.02-0796 |
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