4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride

4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride Suppliers list

Company Name:	Jiangxi Fanlai Biomedical Technology Co., Ltd. Gold
Tel:	17080805366
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Company Name:	Suzhou Junch Pharmaceutical Co., Ltd Gold
Tel:	18625279558; 18625279558
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Company Name:	Pushan Industry (Shaanxi) Co., Ltd. Gold
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4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride manufacturers

4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride Basic information

Product Name:	4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride
Synonyms:	3-b][1;4-AMino-2-Methyl-10H-thieno[2;5] benzodiazapine HCl;4-Amino-2-methyl-10H-thienol[2.3-B][1.5] Benzodiazepine HCl;4-AMino-2-Methyl-10H-thienol[2.3-B][1.5]benzodiazepine hydrochloride;2-Methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-aMine Hydrochloride;OlanzaMine;4-AMino-2-Methyl-10H-Thiene[2,3-B][1,5]BenzodiazepineHCL
CAS:	138564-60-0
MF:	C12H12ClN3S
MW:	265.76
EINECS:	604-085-0
Product Categories:	Olanzapine;Intermediates;Heterocycles;Amines;Chemical Amines;Aromatics;138564-60-0
Mol File:	138564-60-0.mol

4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride Chemical Properties

Melting point	283-285°C
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO (Slightly), Methanol (Sparingly, Sonicated)
form	Solid
color	Yellow to Dark Beige
InChI	InChI=1S/C12H11N3S.ClH/c1-7-6-8-11(13)14-9-4-2-3-5-10(9)15-12(8)16-7;/h2-6,15H,1H3,(H2,13,14);1H
InChIKey	FDWMAKNNNPSUTL-UHFFFAOYSA-N
SMILES	C12SC(C)=CC=1C(N)=NC1=CC=CC=C1N2.Cl
CAS DataBase Reference	138564-60-0(CAS DataBase Reference)

Safety Information

MSDS Information

4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride Usage And Synthesis

Synthesis	In a 500 mL round-bottom flask equipped with a mechanical stirrer and thermometer, 10.0 g (0.0386 mol) of 5-methyl-2-((2-nitrobenzene)amino)thiophene-3-carboxynitrile (1) and 100 mL of ethanol were added. Then 7.4 g (0.062 mol) of tin powder and 84 mL of 4M hydrochloric acid were added, and the mixture was stirred at 50 °C for 0.5 h. The temperature of the reaction mixture was raised to 85 °C, and stirring was continued for 4 h. The mixture was then cooled to 25 °C and stirred for another 8 h, which resulted in the precipitation of a solid. The precipitated crystals were collected, washed with 20 mL of ethanol, and dried under vacuum. 9.8 g (96%) of 2-methyl-2-(nitrobenzene) ...
Chemical Properties	Yellow Crystaline solid
Uses	Intermediate in the preparation of Olanzapine (O253750).

4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride Preparation Products And Raw materials

Tag:4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride(138564-60-0) Related Product Information

IMp. A (EP): 5-Methyl-2-[(2-nitrophenyl)-aMino]thiophene-3-carbonitrile Olanzapine Impurity(ADP-2b) 2-Amino-5-methyl-3-thiophenecarbonitrile 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile Olanzapine dimer Olanzapine Impurity K (E)-1-(4-(2-Methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-yl)piperazin-1-yl)ethanone Olanzapine ThiolactaM IMpurity Olanzapine ThioacetoxyMethylidene IMpurity Discontinued 2-Propylidenepropanedinitrile Olanzapine LactaM IMpurity 2-(1,2-PhenylenediaMino)-5-Methylthiphene-3-carbonitrile 1-(ChloroMethyl)-1-Methyl-4-(2-Methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-yl)-piperaziniuM Chloride Olanzapine Benzoate Olanzapine Impurity(ADP-2c) 1-Fluoro-2-nitrobenzene HydroxyMethylidene thione Olanzapine iMpurity (1-(5'-Methylthiophen-2'-yl)-1,3-dihydrobenzoiMidazol-2-one)