| Identification | Back Directory | [Name]
ML402 | [CAS]
298684-44-3 | [Synonyms]
ML402
ML402;ML-402 ;ML 402
ML402 (TREK-1/2 Activator)
2-Thiophenecarboxamide, N-[2-(4-chloro-2-methylphenoxy)ethyl]- | [Molecular Formula]
C14H14ClNO2S | [MDL Number]
MFCD01990273 | [MOL File]
298684-44-3.mol | [Molecular Weight]
295.78 |
| Chemical Properties | Back Directory | [Boiling point ]
508.4±45.0 °C(Predicted) | [density ]
1.272±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 150 mg/mL (507.13 mM) | [form ]
Solid | [pka]
13.84±0.46(Predicted) | [color ]
White to off-white | [InChI]
1S/C14H14ClNO2S/c1-10-9-11(15)4-5-12(10)18-7-6-16-14(17)13-3-2-8-19-13/h2-5,8-9H,6-7H2,1H3,(H,16,17) | [InChIKey]
RULQUKFOBAPKKR-UHFFFAOYSA-N | [SMILES]
ClC1=CC=C(OCCNC(C2=CC=CS2)=O)C(C)=C1 |
| Hazard Information | Back Directory | [Description]
ML402 is a selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator. | [Uses]
ML402, a thiophene-carboxamide, is a selective K2P2.1(TREK-1) and K2P10.1(TREK-2) activator. ML402 is inactive against K2P4.1(TRAAK)[1]. | [storage]
Store at +4°C | [References]
[1] Lolicato M, et al. K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature. 2017 Jul 20;547(7663):364-368. DOI:10.1038/nature22988 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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