| Identification | Back Directory | [Name]
2-Pyrimidinemethanol, 4-[(2R,6S)-4-(4,6-dimethyl-1,3,5-triazin-2-yl)-2,6-dimethyl-1-piperazinyl]-α-methyl-, (αR)- | [CAS]
300551-49-9 | [Synonyms]
CP642931
CP-642931
CP 642931
UNII-4Q45INJ6TQ
2-Pyrimidinemethanol, 4-[(2R,6S)-4-(4,6-dimethyl-1,3,5-triazin-2-yl)-2,6-dimethyl-1-piperazinyl]-α-methyl-, (αR)-
2-Pyrimidinemethanol, 4-[(2R,6S)-4-(4,6-dimethyl-1,3,5-triazin-2-yl)-2,6-dimethyl-1-piperazinyl]-α-methyl-, (αR)- | [Molecular Formula]
C17H25N7O | [MDL Number]
MFCD05260911 | [MOL File]
300551-49-9.mol | [Molecular Weight]
343.44 |
| Chemical Properties | Back Directory | [Boiling point ]
557.3±60.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.63±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Sorbitol dehydrogenase-IN-1 is a potent and orally active sorbitol dehydrogenase inhibitor with IC50 s of 4, 5 nM for rat and human, respectively.
Sorbitol Dehydrogenase (SDH) is an enzyme that belongs to the zinc-containing alcohol dehydrogenase (ADH) family.
ADH and ALDH are enzymes that work together to metabolize alcohol[1]. | [in vivo]
Sorbitol dehydrogenase-IN-1 (compound 16) (50 μg/kg; p.o.) shows sustained inhibition of sciatic nerve fructose in chronically diabetic rats[1]. | [References]
[1] Mylari BL, et al. A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol. J Med Chem. 2002 Sep 26;45(20):4398-401. DOI:10.1021/jm020288y |
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