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GPR55 agonist 3 (Compound 26) is a GPR55 agonist (EC50: 0.239 nM, and 1.76 nM for hGPR55 and rGPR55). GPR55 agonist 3 induces β-arrestin recruitment to human GPR55 (EC50: 6.2 nM)[1]. | [References]
[1] Hewer RC, et al. Discovery and Characterization of Novel CNS-Penetrant GPR55 Agonists. J Med Chem. 2023 Sep 28;66(18):12858-12876. DOI:10.1021/acs.jmedchem.3c00784 |
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