Chemical Properties | Back Directory | [Boiling point ]
659.332±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.320±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
12.914±0.10(predicted) | [color ]
White to off-white |
Hazard Information | Back Directory | [Uses]
Anticancer agent 241 (HZ1) is an orally active first-in-class cyclin-dependent kinase like 3 (CDKL3)-specific inhibitor. Anticancer agent 241 shows a strong tumor-suppressing effect, and has the potential to overcome the resistance of CDK4/6 inhibitor[1]. | [in vivo]
Anticancer agent 241 (HZ1; 1 mg/kg; oral gavage; daily for 12-14 days) has anticancer activity in a mouse model of colon cancer[1]. Animal Model: | 6-week-old female athymic nude mice injected with DLD-1 cells[1] | Dosage: | 1 mg/kg | Administration: | Oral gavage; daily for 12-14 days | Result: | Suppressed tumor volume in a mouse model of colon cancer. |
| [References]
[1] Haijiao Zhang, et al. CDKL3 is a targetable regulator of cell cycle progression in cancers. J Clin Invest. 2024 Jul 4:e178428. DOI:10.1172/JCI178428 |
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Company Name: |
Biorbyt Ltd.
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Tel: |
+44 (0)1223 859 353 |
Website: |
http://www.biorbyt.com |
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