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3030492-40-8

3030492-40-8 Structure

3030492-40-8 Structure
IdentificationBack Directory
[Name]

HZ1
[CAS]

3030492-40-8
[Synonyms]

HZ1
[Molecular Formula]

C20H22N6O
[MOL File]

3030492-40-8.mol
[Molecular Weight]

362.43
Chemical PropertiesBack Directory
[Boiling point ]

659.332±65.00 °C(Press: 760.00 Torr)(predicted)
[density ]

1.320±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[form ]

Solid
[pka]

12.914±0.10(predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Anticancer agent 241 (HZ1) is an orally active first-in-class cyclin-dependent kinase like 3 (CDKL3)-specific inhibitor. Anticancer agent 241 shows a strong tumor-suppressing effect, and has the potential to overcome the resistance of CDK4/6 inhibitor[1].
[in vivo]

Anticancer agent 241 (HZ1; 1 mg/kg; oral gavage; daily for 12-14 days) has anticancer activity in a mouse model of colon cancer[1].

Animal Model:6-week-old female athymic nude mice injected with DLD-1 cells[1]
Dosage:1 mg/kg
Administration:Oral gavage; daily for 12-14 days
Result:Suppressed tumor volume in a mouse model of colon cancer.
[References]

[1] Haijiao Zhang, et al. CDKL3 is a targetable regulator of cell cycle progression in cancers. J Clin Invest. 2024 Jul 4:e178428. DOI:10.1172/JCI178428
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