| Identification | Back Directory | [Name]
1-ethyl-6-(pyrrolidin-1-ylsulfonyl)benzo[cd]indol-2(1H)-one | [CAS]
304685-40-3 | [Synonyms]
BRD4-IN-4
WAY-383515
1-ethyl-6-(pyrrolidin-1-ylsulfonyl)benzo[cd]indol-2(1H)-one
Benz[cd]indol-2(1H)-one, 1-ethyl-6-(1-pyrrolidinylsulfonyl)- | [Molecular Formula]
C17H18N2O3S | [MOL File]
304685-40-3.mol | [Molecular Weight]
330.4 |
| Hazard Information | Back Directory | [Uses]
BRD4-IN-4 (Compound 1) is a BRD4 inhibitor (IC50=6.83 μM). BRD4-IN-4 selectively inhibits MV4-11 cell line proliferation and arrests cell at G1 phase. BRD4-IN-4 can be used for research of MLL leukemia[1]. | [References]
[1] Feng Y, et al. Design, synthesis and biological evaluation of benzo[cd]indol-2(1H)-ones derivatives as BRD4 inhibitors. Eur J Med Chem. 2018 May 25;152:264-273. DOI:10.1016/j.ejmech.2018.04.048 |
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