| Identification | More | [Name]
7-ETHOXYCOUMARIN | [CAS]
31005-02-4 | [Synonyms]
7-ETHOXY-1-BENZOPYRAN-2-ONE
7-ETHOXY-1-BENZOPYRANE-2-ONE
7-ETHOXYCOUMARIN
ETHOXYCOUMARIN, 7-
2H-1-Benzopyran-2-one, 7-ethoxy-
Coumarin, 7-ethoxy-
Ethylumbelliferone
7-ETHOXYCOUMARIN, 99.5%
7-ETHOXYCOUMARIN, FOR FLUORESCENCE
7-ETHOXYCOUMARIN CRYSTALLINE
7-Ethoxycoumarin, 99.50%
ETHOXYCOUMARIN, 7-(RG)
ETHOXYCOUMARIN
7-Ethoxycoumarin ,99%
7-Ethoxy-2H-1-benzopyran-2-one
7-O-Ethylumbelliferone | [EINECS(EC#)]
250-429-4 | [Molecular Formula]
C11H10O3 | [MDL Number]
MFCD00006877 | [Molecular Weight]
190.2 | [MOL File]
31005-02-4.mol |
| Chemical Properties | Back Directory | [Appearance]
BEIGE CRYSTALLINE POWDER | [Melting point ]
88-90 °C (lit.) | [Boiling point ]
265.69°C (rough estimate) | [density ]
1.1803 (rough estimate) | [refractive index ]
1.4260 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Off-White to Pale Brown | [Water Solubility ]
Soluble in hot methanol (very faint turbidity), 95% ethanol (50 mg/ml), DMF, and DMSO. Insoluble in water. | [Usage]
A substrate for CYP2B6 | [Detection Methods]
HPLC,NMR | [BRN ]
146200 | [InChI]
1S/C11H10O3/c1-2-13-9-5-3-8-4-6-11(12)14-10(8)7-9/h3-7H,2H2,1H3 | [InChIKey]
LIFAQMGORKPVDH-UHFFFAOYSA-N | [SMILES]
CCOc1ccc2C=CC(=O)Oc2c1 | [LogP]
2.310 (est) | [CAS DataBase Reference]
31005-02-4(CAS DataBase Reference) | [Storage Precautions]
Light sensitive |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [F ]
8 | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HS Code ]
29329990 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Description]
7-Ethoxycoumarin is oneof the general substrates for liver cytochrome P450 enzymes, and it is known that CYP1A1,1A2, and 2B1, drug inducedtypes (b-naphthoflavone, isosafrole, and phenobarbital,re-spectively, in rat liver) are mainly responsible for the ECDE activity in the liver. | [Chemical Properties]
BEIGE CRYSTALLINE POWDER | [Uses]
7-Ethoxycoumarin is a substrate for CYP2B6 used in fluorometric assays of microsomal monooxygenase activity. | [Uses]
7-Ethoxycoumarin is commonly used for metabolism studies, including hepatocyte studies, liver perfusion techniques and cytochrome P450 studies.
7-Ethoxycoumarin has been used to study the functional activity of recombinant P450. ) It has also been used as an internal standard for in vitro S-warfarin 7-hydroxylation and high performance liquid chromatography (HPLC) analysis. | [Definition]
ChEBI: 7-ethoxycoumarin is a member of the class of coumarins that is umbelliferone in which the hydroxy group at position 7 is replaced by an ethoxy group. It is an aromatic ether and a member of coumarins. It derives from an umbelliferone. | [Biochem/physiol Actions]
7-Ethoxycoumarin is a cytochrome P450 substrate. | [Metabolism]
7-Ethoxycoumarin is metabolized by many cytochrome P450 enzymes active in foreign compound metabolism and has been used as a prototypic substrate to monitor P450 (P450) activity in both hepatic and extrahepatic tissues.
The in vitro perfusion of the human placental lobule with 7-ethoxycoumarin gives 7-hydroxycoumarin, and perfusion with androstenedione gives the conversion products, estrone, estradiol, and testosterone. The human placenta has only a limited capacity for the metabolism of xenobiotics.
Use of 7-Ethoxycoumarin to Monitor Multiple Enzymes in the Human CYP1, CYP2, and CYP3 Families |
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