| Identification | Back Directory | [Name]
Ethane,1,1'-Oxybis〔2-(2-bromoethoxy)- | [CAS]
31255-26-2 | [Synonyms]
Br-PEG3-Br
Br-PEG4-Br
CAS_31255-26-2
Br-PEG3-bromide
Br-PEG3-CH2CH2Br
Br-(CH2CH2O)4-Br
Bromo-PEG4-bromide
1,11-Dibromo-3,6,9-trioxaundecane
Ethane,1,1'-Oxybis〔2-(2-bromoethoxy)-
1-broMo-2-(2-(2-(2-broMoethoxy)ethoxy)
ethoxy)ethane | [Molecular Formula]
C8H16Br2O3 | [MDL Number]
MFCD18205853 | [MOL File]
31255-26-2.mol | [Molecular Weight]
320.02 |
| Chemical Properties | Back Directory | [Boiling point ]
146 °C(Press: 0.06 Torr) | [density ]
1.5686 g/cm3 | [storage temp. ]
2-8°C | [form ]
Liquid | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C8H16Br2O3/c9-1-3-11-5-7-13-8-6-12-4-2-10/h1-8H2 | [InChIKey]
IJFMWHWXEBUOKR-UHFFFAOYSA-N | [SMILES]
O(CCOCCBr)CCOCCBr |
| Hazard Information | Back Directory | [Description]
Bromo-PEG3-bromide is a PEG linker containing two bromide groups. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
Bromo-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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