| Identification | Back Directory | [Name]
NVP-SAA 164 | [CAS]
312722-60-4 | [Synonyms]
SAA164
SAA-164
SAA 164
NVP-SAA 164
[1-[4-[2,2-DI(PHENYL)ETHYLAMINO]-3-(MORPHOLINE-4-CARBONYL)PHENYL]SULFONYLPIPERIDIN-4-YL]-(4-METHYLPIPERAZIN-1-YL)METHANONE | [Molecular Formula]
C36H45N5O5S | [MDL Number]
MFCD19443778 | [MOL File]
312722-60-4.mol | [Molecular Weight]
659.84 |
| Hazard Information | Back Directory | [Description]
NVP-SAA164 is a nonpeptide bradykinin B1 receptor antagonist. | [Uses]
NVP-SAA164 is an orally active nonpeptide kinin B1 receptor antagonist. NVP-SAA164 reverses CFA (Complete Freund's adjuvant) (HY-153808)-induced mechanical hyperalgesia and desArg10KD-induced hyperalgesia in hB1-KI mice, and is inactive in a model of inflammatory pain in wild-type mice[1]. | [References]
[1] Fox A, et al. Antihyperalgesic activity of a novel nonpeptide bradykinin B1 receptor antagonist in transgenic mice expressing the human B1 receptor. Br J Pharmacol. 2005 Apr;144(7):889-99. DOI:10.1038/sj.bjp.0706139 |
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