| Identification | Back Directory | [Name]
N-(4-methoxyphenyl)-4-(6-methylimidazo[2,1-b][1,3]thiazol-5-yl)-1,3-thiazol-2-amine | [CAS]
315703-81-2 | [Synonyms]
WAY-118959-A
WAY 118959 A,WAY118959A
2-Thiazolamine, N-(4-methoxyphenyl)-4-(6-methylimidazo[2,1-b]thiazol-5-yl)-
N-(4-methoxyphenyl)-4-(6-methylimidazo[2,1-b][1,3]thiazol-5-yl)-1,3-thiazol-2-amine | [Molecular Formula]
C16H14N4OS2 | [MOL File]
315703-81-2.mol | [Molecular Weight]
342.44 |
| Hazard Information | Back Directory | [Uses]
GM-90257 is a microtubule acetylation inhibitor that binds directly to α-tubulin. GM-90257 prevents the recruitment of α-tubulin acetyltransferase 1 (αTAT1) to the K40 residue in α-tubulin. GM-90257 causes the apoptosis of MDA-MB-231 cells with weaker effects on MCF-10A or MCF-7 cells, which have a relatively low level of microtubule acetylation[1]. | [References]
[1] Ahreum Kwon, et al. Potent Small-Molecule Inhibitors Targeting Acetylated Microtubules as Anticancer Agents Against Triple-Negative Breast Cancer. Biomedicines. 2020 Sep 9;8(9):338. DOI:10.3390/biomedicines8090338 |
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| Company Name: |
OTAVA chemicals
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| Tel: |
416 305 9979 (Canada) |
| Website: |
www.otavachemicals.com |
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