| Identification | Back Directory | [Name]
Phortress | [CAS]
328087-38-3 | [Synonyms]
Phortress
Phortress (hydrochloride)
(2S)-2,6-Diamino-N-[4-(5-fluoro-2-benzothiazolyl)-2-methylphenyl]hexanamide dihydrochloride | [Molecular Formula]
C20H25Cl2FN4OS | [MOL File]
328087-38-3.mol | [Molecular Weight]
459.408 |
| Hazard Information | Back Directory | [Uses]
Phortress is a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1[1][2]. | [IC 50]
CYP1 | [storage]
Store at -20°C | [References]
[1] Bradshaw TD, et al. In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles. Br J Cancer. 2002 Apr 22;86(8):1348-54. DOI:10.1038/sj.bjc.6600225
[2] Bradshaw TD, Westwell AD. The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate. Curr Med Chem. 2004 Apr;11(8):1009-21. DOI:10.2174/0929867043455530 |
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