| Identification | More | [Name]
2-Aminobenzenesulfonamide | [CAS]
3306-62-5 | [Synonyms]
2-AMINOBENZENESULFONAMIDE
2-AMINO-BENZENESULFONYL CHLORIDE
2-AMINOBENZENE SULPHONAMIDE
2-AMINOPHENYL SULFONYL CHLORIDE
o-Aminobenzenesulphonamide
2-amino-benzenesulfonamid
o-amino-benzenesulfonamid
o-aminobenzenesulfonamide
orthanilamide
o-sulfanilamide
2-Amino-Benzensulfonamide
D-aminobenzene sulfonamide
Benzenesulfonamide, 2-amino-(9CI)
2-Aminobenzenesulfonamide ,98% | [EINECS(EC#)]
221-988-1 | [Molecular Formula]
C6H8N2O2S | [MDL Number]
MFCD08443599 | [Molecular Weight]
172.2 | [MOL File]
3306-62-5.mol |
| Chemical Properties | Back Directory | [Appearance]
white to pale cream crystalline powder or crystals | [Melting point ]
155-157 °C(lit.)
| [Boiling point ]
392.7±44.0 °C(Predicted) | [density ]
1.3250 (rough estimate) | [refractive index ]
1.6490 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Sparingly), Methanol (Slightly) | [form ]
Solid | [pka]
10.29±0.60(Predicted) | [color ]
Off-White to Beige | [Water Solubility ]
6.655g/L(24 ºC) | [InChI]
InChI=1S/C6H8N2O2S/c7-5-3-1-2-4-6(5)11(8,9)10/h1-4H,7H2,(H2,8,9,10) | [InChIKey]
YAZSBRQTAHVVGE-UHFFFAOYSA-N | [SMILES]
C1(S(N)(=O)=O)=CC=CC=C1N | [CAS DataBase Reference]
3306-62-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S22:Do not breathe dust .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
DA9449000
| [Hazard Note ]
Irritant | [HS Code ]
29350090 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
white to pale cream crystalline powder or crystals | [Uses]
Diuretic;Inhibitor of carbonic anhydrase B | [Definition]
ChEBI: 2-aminobenzenesulfonamide is a sulfonamide and a member of benzenes. | [Synthesis]
General procedure for the synthesis of o-aminobenzenesulfonamide from 2-nitrobenzenesulfonamide: 2-nitrobenzenesulfonamide (80.0 g, 0.58 mol) was dissolved in methanol in the presence of a Pd/C catalyst (10.0 g, 13% w/w) to prepare a solution with a mass concentration of 10%. The hydrogenation reaction was carried out at 50 psi hydrogen pressure and 60°C and the reaction was continued overnight. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to give 60 g of off-white solid o-aminobenzenesulfonamide in 95% yield. | [IC 50]
CA Ⅸ | [Solubility in organics]
2-Aminobenzenesulfonamide is freely soluble in water, glacial acetic acid, ethyl alcohol, acetone, and methanol; insoluble in benzene.
| [References]
[1] Patent: CN104761514, 2016, B. Location in patent: Paragraph 0028-0030
[2] Tetrahedron Letters, 2001, vol. 42, # 33, p. 5601 - 5603
[3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 7, p. 2455 - 2478
[4] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 17, p. 5647 - 5647
[5] Bihang till Svenska Vet.-Akad. Handlingar, vol. 27, p. II, No. 1, S. 4 |
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