| Identification | Back Directory | [Name]
(±)-2-(1H-benzimidazol-2-ylthio)propanoicacid2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide | [CAS]
330676-02-3 | [Synonyms]
KH 7
sAC inhibitor KH7
(E)-2-(1H-Benzo[d]imidazol-2-ylthio)-N′-(5-bromo-2-hydroxybenzylidene)propanehydrazide
(±)-2-(1H-benzimidazol-2-ylthio)propanoicacid2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide
Propanoic acid, 2-(1H-benzimidazol-2-ylthio)-, 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide | [Molecular Formula]
C17H15BrN4O2S | [MDL Number]
MFCD01230899 | [MOL File]
330676-02-3.mol | [Molecular Weight]
419.3 |
| Chemical Properties | Back Directory | [density ]
1.61±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: >20mg/mL | [form ]
powder | [pka]
7.90±0.48(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
KH7 has been used:
- as a soluble adenyl?cyclase?(sAC) antagonist to study its effect on the signaling pathway mediated by the action of transient? receptor type 1 (TRPV1) in sperm cells.
- as a selective sAC antagonist to study its effect on the signaling pathway of proton gated channels (HV1) induced action in sperm cells.
- as a sAC inhibitor to study its effects on cAMP increase in monophosphorylated myosin light chain (pMLC).
| [Biochem/physiol Actions]
KH7 is a selective inhibitor of soluble adenylyl cyclase. Soluble adenylyl cyclase (sAC) is an ubiquitously expressed, essential component of cAMP-signaling. | [storage]
Store at +4°C |
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821-50328103-801 18930552037 |
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Sigma-Aldrich
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Energy Chemical
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http://www.energy-chemical.com |
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