| Identification | More | [Name]
3-Amino-2-pyridinol | [CAS]
33630-99-8 | [Synonyms]
2-HYDROXY-3-AMINO PYRIDINE
3-AMINO-2-HYDROXYPYRIDINE
3-AMINO-2-PYRIDINOL
3-AMINO-PYRIDIN-2-OL
3-AMINO-2-HYDROXYPYRIDINE 99%
3-Amino-2(1H)-pyridinone
3-Amino-2-hydroxypyridine
3-Amino-2-pyridinol
3-Amino-2-hydroxypyridine ,98% | [Molecular Formula]
C5H6N2O | [MDL Number]
MFCD03411556 | [Molecular Weight]
110.11 | [MOL File]
33630-99-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Brown to off-white crystalline powder. | [Melting point ]
118-130 °C
| [Boiling point ]
206.4°C (rough estimate) | [density ]
1.2111 (rough estimate) | [refractive index ]
1.4800 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
Powder | [pka]
13.87±0.10(Predicted) | [color ]
Dark brown to black | [Water Solubility ]
Slightly soluble in water. | [Detection Methods]
HPLC | [InChI]
InChI=1S/C5H6N2O/c6-4-2-1-3-7-5(4)8/h1-3H,6H2,(H,7,8) | [InChIKey]
VTSFNCCQCOEPKF-UHFFFAOYSA-N | [SMILES]
C1(=O)NC=CC=C1N | [CAS DataBase Reference]
33630-99-8(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Uses]
3-Amino-2-hydroxypyridine has been used as a reactant in the preparation of benzothiazolyl hydroxyindolinylphenyl ureas as potent P2Y1 antagonists. |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
WGK 3 | [HazardClass ]
IRRITANT | [HS Code ]
29333990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Brown to off-white crystalline powder. | [Synthesis]
a) Synthesis of 3-aminopyridin-2-ol: In a 500 mL three-necked flask, 3-nitropyridin-2(1H)-one (1 g, 7.14 mmol) was dissolved in methanol (200 mL), followed by addition of 10% palladium/activated carbon catalyst (100 mg, 10 wt%). The reaction mixture was stirred for 3 h under hydrogen atmosphere (1 atm) and at room temperature (25°C). Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad, and the filtrate was concentrated under reduced pressure by rotary evaporator to afford the white solid product 3-aminopyridin-2-ol (800 mg, quantitative yield). Product characterization data: 1H-NMR (CD3OD, 300 MHz) δ 6.78-6.73 (m, 2H), 6.23 (t, J = 6.5 Hz, 1H); MS (ESI) m/z 111.1 [M+H]+. | [References]
[1] Patent: US2011/28467, 2011, A1. Location in patent: Page/Page column 14
[2] Patent: WO2006/51410, 2006, A1. Location in patent: Page/Page column 46
[3] Heterocycles, 1990, vol. 31, # 12, p. 2201 - 2204
[4] Heterocycles, 1990, vol. 31, # 12, p. 2201 - 2204
[5] Recueil des Travaux Chimiques des Pays-Bas, 1949, vol. 68, p. 1013,1024 |
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