| Identification | More | [Name]
1,3-Bis(4,5-dihydro-2-oxazolyl)benzene | [CAS]
34052-90-9 | [Synonyms]
1,3-BIS(2-OXAZOLIN-2-YL)BENZENE
1,3-BIS(4,5-DIHYDRO-2-OXAZOLYL)BENZENE
1,3-PBO
1,3-PHENYLENBISOXAZOLINE
1,3-Phenylene-bis-oxazoline
2,2'-(1,3-phenylene)bis-2-oxazolin
2,2'-(1,3-PHENYLENE)BIS(2-OXAZOLINE)
2,2’-(1,3-phenylene)bis(4,5-dihydro)-Oxazole
bisdihydrooxazolylbenzene
2,2′-(1,3-Phenyl)bis(2-oxazolin)
2'-(1,3-Phenylene)bis-2-oxazoline
1,3-BIS(4,5-DIHYDRO-2-OXAZOLYL)BENZENE 98+%
1,3-Bis(4,5-dihydrooxazole-2-yl)benzene | [EINECS(EC#)]
421-510-3 | [Molecular Formula]
C12H12N2O2 | [MDL Number]
MFCD00191606 | [Molecular Weight]
216.24 | [MOL File]
34052-90-9.mol |
| Safety Data | Back Directory | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [HS Code ]
2934.99.4400 |
| Hazard Information | Back Directory | [Definition]
Bisoxazoline is an essential organic reaction intermediate. It is a five-membered heterocyclic compound containing two carbons, nitrogen, oxygen and a carbon-nitrogen double bond. Because of its active chemical properties, it can undergo ring-opening reactions with carboxyl, anhydride, amino, epoxy, thiol, phenolic hydroxyl, isocyanate, etc., at a certain temperature. Therefore, bisoxazoline can often be used as a chain extender or cross-linking agent for polymers.
| [Synthesis]
GENERAL METHOD: A mixture of isophthalonitrile (0.5 mmol), 2-aminoethanol (0.65 mmol, 0.040 g), Co(NO3)2 (0.02 mmol, 0.036 g), and sulfur (0.05 mmol, 0.0016 g) was stirred for an appropriate period of time at 90 °C, or reacted under microwave radiation (90 °C, 800 W) for the corresponding Time. For the synthesis of monooxazolines, a mixture of isophthalonitrile (0.5 mmol), 2-aminoethanol (0.65 mmol, 0.040 g), Co(NO3)2 (0.02 mmol, 0.036 g) and sulfur (0.05 mmol, 0.0016 g) was stirred for 3 h at 90 °C or reacted under microwave radiation conditions (90 °C, 800 W) for 3 min . For the synthesis of bisoxazoline, isophthalonitrile (0.5 mmol), 2-aminoethanol (2.6 mmol, 0.159 g), Co(NO3)2 (0.02 mmol, 0.036 g), and sulfur (0.05 mmol, 0.0016 g) were stirred for 10 hr at 110 °C or reacted under microwave radiation conditions (110 °C, 800 W) for 8 minutes. After completion of the reaction (monitored by TLC), the reaction mixture was cooled to room temperature, ethyl acetate (6 mL) was added and the catalyst was separated by filtration. After concentration under reduced pressure, the residue was purified by silica gel column chromatography to afford the pure product 1,3-bis(4,5-dihydrooxazol-2-yl)benzene (5a-r). | [References]
[1] Journal of Organic Chemistry, 2015, vol. 80, # 20, p. 9910 - 9914
[2] Synlett, 2005, # 18, p. 2747 - 2750
[3] Tetrahedron, 2013, vol. 69, # 32, p. 6591 - 6597
[4] Monatshefte fur Chemie, 2009, vol. 140, # 12, p. 1489 - 1494
[5] Journal of the Serbian Chemical Society, 2012, vol. 77, # 9, p. 1181 - 1189,9 |
| Spectrum Detail | Back Directory | [Spectrum Detail]
1,3-Bis(4,5-dihydro-2-oxazolyl)benzene(34052-90-9)MS
1,3-Bis(4,5-dihydro-2-oxazolyl)benzene(34052-90-9)1HNMR
1,3-Bis(4,5-dihydro-2-oxazolyl)benzene(34052-90-9)13CNMR
1,3-Bis(4,5-dihydro-2-oxazolyl)benzene(34052-90-9)IR1
1,3-Bis(4,5-dihydro-2-oxazolyl)benzene(34052-90-9)IR2
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