| Identification | Back Directory | [Name]
H2N-PEG12-CH2CH2NH2 | [CAS]
361543-12-6 | [Synonyms]
PEODA13
H2N-PEG12-NH2
H2N-PEG12-CH2CH2NH2 | [Molecular Formula]
C26H56N2O12 | [MDL Number]
MFCD31704944 | [MOL File]
361543-12-6.mol | [Molecular Weight]
588.73 |
| Chemical Properties | Back Directory | [Boiling point ]
621.3±50.0 °C(Predicted) | [density ]
1.087±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, protect from light | [solubility ]
Soluble in water, DMSO, DCM and DMF | [form ]
Solid-Liquid Mixture | [pka]
9.04±0.10(Predicted) | [color ]
Colorless to off-white | [InChI]
InChI=1S/C26H56N2O12/c27-1-3-29-5-7-31-9-11-33-13-15-35-17-19-37-21-23-39-25-26-40-24-22-38-20-18-36-16-14-34-12-10-32-8-6-30-4-2-28/h1-28H2 | [InChIKey]
LBBOTXXNKBSUJN-UHFFFAOYSA-N | [SMILES]
C(N)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN |
| Hazard Information | Back Directory | [Description]
H2N-PEG12-CH2CH2NH2 (CAS 361543-12-6), also known as Amino-PEG12-amine or NH2-PEG12-NH2, is a PEG linker containing two amino groups (NH₂). The hydrophilic PEG spacer enhances its solubility in aqueous media. Its amino groups can react with carboxylic acids, activated NHS esters, and carbonyl groups (ketones, aldehydes), amongst others. | [Uses]
Amino-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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