| Identification | Back Directory | [Name]
(N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol | [CAS]
362512-81-0 | [Synonyms]
TC 1
(N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol | [Molecular Formula]
C19H20FNO | [MDL Number]
MFCD09971115 | [MOL File]
362512-81-0.mol | [Molecular Weight]
297.367 |
| Chemical Properties | Back Directory | [Melting point ]
159-160 °C | [Boiling point ]
413.7±30.0 °C(Predicted) | [density ]
1.462±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
Soluble to 50 mM in DMSO with gentle warming and to 50 mM in ethanol with gentle warming | [form ]
Powder | [pka]
13.82±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
TC 1 is a novel σ-receptor ligand derived from 4-azahexacyclo [5.4.1.02,6.03,10.05,9.08,11]dodecane, which modulates amphetamine-stimulated [3H] dopamine release. | [Definition]
ChEBI: LSM-1328 is a sesquiterpenoid. | [in vivo]
σ1 Receptor antagonist 4 (compound TC1; 3-100 mg/kg; ip; once) attenuats the stimulatory locomotor effect of 20 mg/kg Cocaine with a half-maximal depressant activity (ID50) of 38.6 mg/kg[1]. | Animal Model: | Male Swiss-Webster mice (Hsd:ND4, aged 2-3 month) injected with Cocaine[1] | | Dosage: | 3 mg/kg, 10 mg/kg, 30 mg/kg, 100 mg/kg | | Administration: | i.p.; once | | Result: | Attenuated the stimulatory locomotor effect of 20 mg/kg Cocaine. |
| [IC 50]
σ1R: 10 nM (Ki); σ2: 370 nM (Ki) | [storage]
Store at RT |
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