| Identification | More | [Name]
3,4-Diaminofluorobenzene | [CAS]
367-31-7 | [Synonyms]
1,2-DIAMINO-4-FLUOROBENZENE
3,4-DIAMINO-1-FLUOROBENZENE
3,4-DIAMINOFLUOROBENZENE
4-FLUORO-1,2-DIAMINOBENZENE
4-FLUORO-1,2-PHENYLENEDIAMINE
4-FLUORO-BENZENE-1,2-DIAMINE
4-FLUORO-O-PHENYLENEDIAMINE
1,2-Diamino-4-fluorobenzene~3,4-Diaminofluorobenzene
Fluoroophenylenediamine
3,4-Diaminofluorobenzene 98%
3,4-Diaminofluorobenzene98%
4-Fluoro-1,2-benzenediamine
1,2-Diamino-4-fluorobenzene, 4-Fluoro-o-phenylenediamine | [EINECS(EC#)]
206-691-7 | [Molecular Formula]
C6H7FN2 | [MDL Number]
MFCD00042228 | [Molecular Weight]
126.13 | [MOL File]
367-31-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
94-98 °C | [Boiling point ]
266.1±20.0 °C(Predicted) | [density ]
1.284±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
4.22±0.10(Predicted) | [color ]
deep brown
| [Water Solubility ]
Slightly soluble in water. | [Sensitive ]
Light Sensitive | [BRN ]
2081075 | [InChI]
InChI=1S/C6H7FN2/c7-4-1-2-5(8)6(9)3-4/h1-3H,8-9H2 | [InChIKey]
KWEWNOOZQVJONF-UHFFFAOYSA-N | [SMILES]
C1(N)=CC=C(F)C=C1N | [CAS DataBase Reference]
367-31-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN2811 | [WGK Germany ]
3
| [F ]
8 | [Hazard Note ]
Irritant | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29215110 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
White to brown powder | [Uses]
4-Fluoro-o-phenylenediamine is used as pharmaceutical intermediate. | [Synthesis]
General procedure for the synthesis of 4-fluoro-1,2-benzenediamine from 5-fluoro-2-nitroaniline: a methanol solution of 5-fluoro-2-nitroaniline (0.32 M) was added to a palladium/carbon catalyst (5% w/w, 10% w). The reaction mixture was stirred for 2 h at room temperature under hydrogen atmosphere (50 psi). Upon completion of the reaction, the mixture was filtered to remove the catalyst and the filtrate was concentrated to afford 4-fluoro-1,2-benzenediamine in 90% yield as a brown oil. Mass spectrometry (electrospray positive ion mode) analysis: the theoretical molecular weight of C6H7FN2 was 126 and the measured value was 127 (M + H)+. | [References]
[1] Macromolecules, 2005, vol. 38, # 2, p. 297 - 306
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994, # 19, p. 2751 - 2758
[3] Patent: WO2010/13037, 2010, A1. Location in patent: Page/Page column 67
[4] Synlett, 2018, vol. 29, # 13, p. 1765 - 1768
[5] Tetrahedron, 2017, vol. 73, # 27-28, p. 3898 - 3904 |
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