| Identification | More | [Name]
2,2,2-Trifluoroethylamine hydrochloride | [CAS]
373-88-6 | [Synonyms]
2,2,2-TRIFLUOROETHYLAMINE HYDROCHLORIDE
2,2,2-TRIFLUORO-ETHYL-AMMONIUM CHLORIDE
2-AMINO-1,1,1-TRIFLUOROETHANE HYDROCHLORIDE
TAF
TRIFLUOROETHYLAMINE HYDROCHLORIDE
2,2,2-trifluoro-ethanaminhydrochloride
trifluoro-ethylaminhydrochloride
2,2,2-TrifluoroethylamineHCl
2,2,2-Trifluoroethylamine hydrochloride 98%
2,2,2-Trifluoroethylaminehydrochloride98%
2,2,2-Trifluoroethylamine hydrochloride(99%)
2,2,2-Trifluoroethanamine hydrochloride | [EINECS(EC#)]
206-771-1 | [Molecular Formula]
C2H5ClF3N | [MDL Number]
MFCD00012875 | [Molecular Weight]
135.52 | [MOL File]
373-88-6.mol |
| Chemical Properties | Back Directory | [Appearance]
WHITE TO LIGHT YELLOW CRYSTALLINE POWDER | [Melting point ]
220-222 °C (subl.)(lit.)
| [density ]
1,24g/cm | [refractive index ]
1,3-1,302 | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
powder to crystal | [color ]
White to Light yellow to Light orange | [Water Solubility ]
It is Soluble in 0.7 to water, but soluble in ethanol and chloroform, slightly soluble in benzene, hardly soluble in ether. | [Sensitive ]
Hygroscopic | [BRN ]
3652103 | [InChI]
InChI=1S/C2H4F3N.ClH/c3-2(4,5)1-6;/h1,6H2;1H | [InChIKey]
ZTUJDPKOHPKRMO-UHFFFAOYSA-N | [SMILES]
C(F)(F)(F)CN.Cl | [CAS DataBase Reference]
373-88-6(CAS DataBase Reference) | [EPA Substance Registry System]
373-88-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,T,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
KS0250000
| [F ]
3-10-21 | [Hazard Note ]
Hygroscopic/Toxic | [TSCA ]
T | [HazardClass ]
IRRITANT | [PackingGroup ]
III | [HS Code ]
29211990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral | [Toxicity]
LD50 unr-mus: 476 mg/kg 11FYAN 3,81,63 |
| Hazard Information | Back Directory | [Chemical Properties]
WHITE TO LIGHT YELLOW CRYSTALLINE POWDER | [Uses]
2,2,2-Trifluoroethylamine Hydrochloride is a reagent in the synthesis of arachidonylethanolamide analogs. These show affinity for CB1 and CB2 cannabinoid receptors. | [Safety Profile]
Moderately toxic by unspecifiedroute. When heated to decomposition it emits very toxicfumes of F??, NOx, and HCl. | [Synthesis]
General procedure for the synthesis of 2,2,2-trifluoroethylamine hydrochloride from 2,2,2-trifluoroethylamine: 100 g of ethanol and 33 g of 2,2,2-trifluoroethylamine were added to a triple-necked flask, and 35 g of saturated hydrochloric acid solution was added slowly and dropwise at temperatures lower than 25°C. The reaction system was then brought up to 50°C and maintained there for 1 hour. After the dropwise addition, the temperature of the reaction system was raised to 50 °C and maintained for 1 hour. Subsequently, the temperature of the reaction solution was controlled to be 45±5°C under a vacuum of 0.98 MPa and a decompression distillation was carried out for 5 hours to remove water and ethanol. Finally 43.5 g of 2,2,2-trifluoroethylamine hydrochloride was obtained in 96.30% yield. The resulting product was a white powdery crystalline solid with 0.13% water. | [References]
[1] Patent: CN105801428, 2016, A. Location in patent: Paragraph 0016; 0017 |
| Spectrum Detail | Back Directory | [Spectrum Detail]
2,2,2-Trifluoroethylamine hydrochloride(373-88-6)MS
2,2,2-Trifluoroethylamine hydrochloride(373-88-6)1HNMR
2,2,2-Trifluoroethylamine hydrochloride(373-88-6)IR1
2,2,2-Trifluoroethylamine hydrochloride(373-88-6)IR2
2,2,2-Trifluoroethylamine hydrochloride(373-88-6)Raman
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