| Identification | More | [Name]
Difluoroacetic acid | [CAS]
381-73-7 | [Synonyms]
1,1-DIFLUOROACETIC ACID
2,2-DIFLUOROACETIC ACID
DIFLUOROACETIC ACID
VITAS-BB TBB000649
Acetic acid, difluoro-
difluoro-aceticaci
Difluoroaceticacid98%
DIFLUOROACETATE | [EINECS(EC#)]
206-839-0 | [Molecular Formula]
C2H2F2O2 | [MDL Number]
MFCD00004220 | [Molecular Weight]
96.03 | [MOL File]
381-73-7.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to light brown liquid | [Melting point ]
-1 °C (lit.) | [Boiling point ]
132-134 °C (lit.) | [density ]
1.526 g/mL at 25 °C(lit.)
| [vapor pressure ]
11.7hPa at 25℃ | [refractive index ]
n20/D 1.344(lit.)
| [Fp ]
174 °F
| [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
540.54g/L in organic solvents at 20 ℃ | [form ]
Liquid | [pka]
pK1:1.33 (25°C) | [color ]
Clear colorless to light brown | [Specific Gravity]
1.527 (20℃) | [Water Solubility ]
1000g/L at 37℃ | [BRN ]
1098588 | [InChIKey]
PBWZKZYHONABLN-UHFFFAOYSA-N | [LogP]
0.601 at 37℃ | [CAS DataBase Reference]
381-73-7(CAS DataBase Reference) | [NIST Chemistry Reference]
Difluoroacetic acid(381-73-7) | [EPA Substance Registry System]
381-73-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns.
R35:Causes severe burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3265 8/PG 2
| [WGK Germany ]
3
| [RTECS ]
AG9900000
| [Hazard Note ]
Corrosive | [TSCA ]
T | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29159080 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to light brown liquid | [Uses]
Used in the preparation of 2-difluoromethylbenzimidazoles, -oxazoles and -thiazoles from ortho-substituted anilines mediated by triphenylphoshine. | [Definition]
ChEBI: A monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by fluorines. | [Flammability and Explosibility]
Nonflammable | [Purification Methods]
Purify the acid by distilling over P2O5. The acid chloride is a fuming liquid b 25o/atm, and the amide has b 108.6o/35mm, m 52o (from *C6H6), and the anilide has b 90o/1mm, 114o/5mm, m 58o [Henne & Pelley J Am Chem Soc 74 1426 1952, Coffman et al. J Org Chem 14 749 1949, NMR: Meyer et al. J Am Chem Soc 75 4567 1953, pK: Wegscheider Z Phys Chem 69 614 1909]. [Beilstein 2 IV 455.] |
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