| Identification | More | [Name]
Thiomorpholine-1,1-dioxide | [CAS]
39093-93-1 | [Synonyms]
1,1-DIOXIDE-4-THIOMORPHOLINE
1,1-DIOXOTHIOMORPHOLINE
THIOMORPHOLINE 1,1-DIOXIDE
THIOMORPHOLINE DIOXIDE
TIMTEC-BB SBB010267
Thiomorpholine-1,1-oxide | [EINECS(EC#)]
815-944-6 | [Molecular Formula]
C4H9NO2S | [MDL Number]
MFCD05861623 | [Molecular Weight]
135.18 | [MOL File]
39093-93-1.mol |
| Chemical Properties | Back Directory | [Appearance]
light yellow solid | [Melting point ]
0°C | [Boiling point ]
0°C | [density ]
1.239±0.06 g/cm3(Predicted) | [Fp ]
0°C | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
6.48±0.20(Predicted) | [color ]
White to Off-White | [InChI]
InChI=1S/C4H9NO2S/c6-8(7)3-1-5-2-4-8/h5H,1-4H2 | [InChIKey]
NDOVLWQBFFJETK-UHFFFAOYSA-N | [SMILES]
N1CCS(=O)(=O)CC1 | [CAS DataBase Reference]
39093-93-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
light yellow solid | [Uses]
Thiomorpholine 1,1-Dioxide is a useful building block, used in the synthetic preparation of antibacterial biaryloxazolidinone analogues, and isothiazolo-pyridine derivatives for use as cyclin G-associated kinase inhibitors and antiviral agents. | [Synthesis]
To a solution of tert-butylthiomorpholine-4-carboxylate (5.8 g, 0.024 mol) in dichloromethane (50 ml) was added trifluoroacetic acid (70 ml), and the resulting mixture was stirred at 25°C. 5 hours until TLC showed the reaction was complete. Concentrate under reduced pressure to obtain a mixture. Water (30 mL) was added to the mixture, the mixture was basified to pH=8.0 with aqueous ammonia solution, and the mixture was extracted three times with dichloromethane (50 mLx3). The organic extracts were combined and washed with water and brine. The organic extract was dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated under reduced pressure to obtain Thiomorpholine 1,1-dioxide.
| [References]
[1] European Journal of Medicinal Chemistry, 2018, vol. 158, p. 247 - 258
[2] Patent: US2006/100426, 2006, A1. Location in patent: Page/Page column 17
[3] Patent: US2006/135764, 2006, A1. Location in patent: Page/Page column 21
[4] Patent: US2006/100236, 2006, A1. Location in patent: Page/Page column 19
[5] Patent: US2006/199839, 2006, A1. Location in patent: Page/Page column 21 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
Aemon Chemical
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0086-755-86198205 |
| Website: |
www.aemonchem.com |
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