| Identification | More | [Name]
3-Fluoro-4-methylpyridine | [CAS]
399-88-2 | [Synonyms]
3-FLUORO-4-METHYLPYRIDINE
3-FLUORO-4-PICOLINE
3-FLUORO-4-METHYLPYRIDINE (3-FLUORO-4-PICOLINE)
4-METHYL-3-FLUOROPYRIDINE | [EINECS(EC#)]
675-120-5 | [Molecular Formula]
C6H6FN | [MDL Number]
MFCD04114226 | [Molecular Weight]
111.12 | [MOL File]
399-88-2.mol |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
1993 | [HazardClass ]
3 | [PackingGroup ]
Ⅲ | [HS Code ]
2933399990 |
| Hazard Information | Back Directory | [Synthesis]
3-Fluoro-4-methylpyridine To a cooled (-78℃) solution of N, N-diisopropylamine (15.92mL, 113.4mmol) in THF (14OmL) a solution of BuLi 2.5M in hexane (45.4ml, 113.4 mmol) was added dropwise over 30 minutes under an atmosphere of Argon. The mixture was stirred for 30 min. at - 78℃ and a solution of 3-fluoropyridine (10g, 103.1 mmol) in THF (5ml) was added. After 1h at -780C, the mixture was treated with MeI (7 ml, 113.4mmol) and then was allowed to reach 250C. A solution of NaHCO3 saturated (30ml) was added and the aqueous phase was extracted with diethyl ether. The organic layer was dried (MgSO4) and upon distillation the product was collected as a colourless liquid 3-Fluoro-4-methylpyridine, bp 1300C, yield 5.3 g (47percent).
| [References]
[1] Patent: WO2007/17096, 2007, A1. Location in patent: Page/Page column 70-71
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 4, p. 461 - 473
[3] Patent: US6455532, 2002, B1
[4] Patent: US6350745, 2002, B1. Location in patent: Page column 15;16
[5] Patent: WO2006/35967, 2006, A1. Location in patent: Page/Page column 98-99 |
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