| Identification | More | [Name]
2-Bromo-3-fluorophenol | [CAS]
443-81-2 | [Synonyms]
2-BROMO-3-FLUOROPHENOL
3-Fluoro-2-bromophenol | [Molecular Formula]
C6H4BrFO | [MDL Number]
MFCD04037220 | [Molecular Weight]
191 | [MOL File]
443-81-2.mol |
| Chemical Properties | Back Directory | [Appearance]
light yellow liquid | [Boiling point ]
123 °C(Press: 50 Torr) | [density ]
1.764±0.06 g/cm3(Predicted) | [refractive index ]
1.56 | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
clear liquid | [pka]
7.43±0.10(Predicted) | [color ]
Colorless to Light yellow to Light orange | [CAS DataBase Reference]
443-81-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [HS Code ]
2908190090 |
| Hazard Information | Back Directory | [Description]
2-Bromo-3-fluorophenol(443-81-2) is a chemical intermediate commonly used in organic synthesis and laboratory research. It can be used to prepare monofluorophenol.
| [Chemical Properties]
light yellow liquid | [Uses]
2-Bromo-3-fluorophenol(443-81-2) has been used as a reactant in the preparation of diaryl ethers.
| [Synthesis]
1. 120 mL of isopropanol, 200 mL of 6M hydrochloric acid and 81 g (345 mmol) of 1-(methoxymethoxy)-2-bromo-3-fluorophenol were mixed and stirred for 2.5 hours at room temperature.
2. Upon completion of the reaction, the reaction mixture was partitioned. 400 ml of methyl tert-butyl ether and 120 ml of 5N sodium hydroxide were added.
3. The organic phase was separated, washed with saturated aqueous sodium chloride solution and then dried over anhydrous sodium sulfate.
4. The dried organic phase is concentrated under pressure to give an oily residue.
5. purify the residue by silica gel column chromatography and collect the fraction containing 2-bromo-3-fluorophenol.
6. Concentrate the combined fractions under pressure to give 55.1 g (84% yield) of the target compound 2-bromo-3-fluorophenol as a colorless oil. | [References]
[1] Patent: EP1204660, 2004, B1. Location in patent: Page 19 |
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