| Identification | More | [Name]
2-Fluorobenzyl bromide | [CAS]
446-48-0 | [Synonyms]
1-(BROMOMETHYL)-2-FLUORO-BENZENE
2-FLUOROBENZYL BROMIDE
ALPHA-BROMO-2-FLUOROTOLUENE
ALPHA-BROMO-O-FLUOROTOLUENE
O-FLUOROBENZYL BROMIDE
Benzene, 1-(bromomethyl)-2-fluoro-
α-Bromo-2-fluorotoluene
2-fluoro(bromomethyl)benzene
2-FLUOROBENZYL BROMIDE 98%
2-Fluorobenzylbromide,98%
à-bromo-2-fluorotoluene
1-Fluoro-2-(bromomethyl)benzene | [EINECS(EC#)]
207-169-1 | [Molecular Formula]
C7H6BrF | [MDL Number]
MFCD00000324 | [Molecular Weight]
189.02 | [MOL File]
446-48-0.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to slightly yellow liquid | [Boiling point ]
84-85 °C15 mm Hg(lit.)
| [density ]
1.567 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.552(lit.)
| [Fp ]
181 °F
| [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Liquid | [color ]
Clear colorless to slightly yellow | [Specific Gravity]
1.567 | [Sensitive ]
Lachrymatory | [Detection Methods]
GC | [BRN ]
1099894 | [InChI]
InChI=1S/C7H6BrF/c8-5-6-3-1-2-4-7(6)9/h1-4H,5H2 | [InChIKey]
FFWQLZFIMNTUCZ-UHFFFAOYSA-N | [SMILES]
C1(CBr)=CC=CC=C1F | [CAS DataBase Reference]
446-48-0(CAS DataBase Reference) | [NIST Chemistry Reference]
2-Fluorobenzyl bromide(446-48-0) | [Storage Precautions]
Moisture sensitive;Store under nitrogen |
| Questions And Answer | Back Directory | [Synthesis]
Method 1,
Mix 2-fluorotoluene, N-bromosuccinimide, benzoyl peroxide, and chloroform. Purge with argon gas, maintaining a pressure of 2 atmospheres and a temperature of 100°C. Stir for 1.5 hours to obtain a mixture containing 2-fluorobenzyl bromide.
Method 2, 
At 0°C, add CBr4 (31.6 g, 95.2 mmol) in small batches to a DCM solution of (2-fluorophenyl)methanol (Aldrich, 10.0 g, 79.3 mmol) and triphenylphosphine (29.1 g, 111 mmol). Stir the mixture at room temperature for 2 hours. The solvent was evaporated, and the residue was purified by rapid chromatography (cyclohexane:ethyl acetate 95:5) to give 2-fluorobenzyl bromide (14 g, 93%). |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H314-H335 | [Precautionary statements ]
P261-P271-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns.
R36/37:Irritating to eyes and respiratory system . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S27:Take off immediately all contaminated clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3265 8/PG 2
| [WGK Germany ]
3
| [Hazard Note ]
Corrosive/Lachrymatory | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29039990 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Skin Corr. 1B
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to slightly yellow liquid | [Uses]
2-Fluorobenzyl bromide was used:
- in the synthesis of 2-pyrrolo[2,3-d]pyrimidines
- as alkylating agent during the synthesis of 8-alkylated imidazolo[1,2-a]pyrimid-5-ones
- in the synthesis of prasugrel
|
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
|