| Identification | Back Directory | [Name]
N-[2-(3,4-dimethoxyphenyl)ethyl]-6-methylthieno[2,3-d]pyrimidin-4-amine | [CAS]
452087-38-6 | [Synonyms]
CIA1
N-[2-(3,4-dimethoxyphenyl)ethyl]-6-methylthieno[2,3-d]pyrimidin-4-amine
Thieno[2,3-d]pyrimidin-4-amine, N-[2-(3,4-dimethoxyphenyl)ethyl]-6-methyl- | [Molecular Formula]
C17H19N3O2S | [MOL File]
452087-38-6.mol | [Molecular Weight]
329.42 |
| Chemical Properties | Back Directory | [Boiling point ]
529.6±50.0 °C(Predicted) | [density ]
1.264±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
5.40±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
NR2F2-IN-1 (free base) is a potent and selective orphan nuclear receptor COUP-TFII (NR2F2) inhibitor. NR2F2-IN-1 (free base) substantially inhibits COUP-TFII–driven NGFIA reporter expression. NR2F2-IN-1 (free base) directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators, including FOXA1, thus repressing COUP-TFII activity on target gene regulation[1]. | [References]
[1] Leiming Wang, et al. Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Sci Adv. 2020 Apr 29;6(18):eaaz8031. DOI:10.1126/sciadv.aaz8031 |
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